Hello Sinosphere,
would you mind giving us a bit more specifics/detail about your setup?
In general you can use Octopus and Nemo to address 32 MIDI channels, including all controllers (CC) on each of the channels.
I understand that you would like to make Octopus something like the centerpiece of your setup, but to give you an opinion, I need to understand better what you have in mind.
Cheers,
Gabriel